Prepare the Patties: In a mixing bowl, combine the ground beef, salt, pepper, garlic powder, onion powder, and Worcestershire sauce. Mix until just combined—don't overwork the meat to keep the patties tender. Shape the mixture into 4 equal-sized patties. Use your thumb to make a small indentation in the center of each patty to help them cook evenly.
Preheat the Air Fryer: Preheat the air fryer to 375°F (190°C) for about 5 minutes. Preheating ensures that the burgers cook evenly from the moment you place them inside.
Air Fry the Patties: Lightly spray the air fryer basket with cooking spray or line it with parchment paper. Place the patties in the basket in a single layer, making sure they don’t touch. Air fry at 375°F (190°C) for 8-10 minutes, flipping halfway through, or until the internal temperature reaches 160°F (71°C) for medium doneness.
Add the Cheese: About 1-2 minutes before the patties are done, place a slice of cheese on each patty and continue to air fry until the cheese is melted and bubbly.
Assemble the Burgers: Toast the burger buns in the air fryer for 1-2 minutes if desired. Place each cooked patty on the bottom half of the bun and top with your favorite toppings. Add lettuce, tomato, pickles, onions, ketchup, or mustard as preferred. Serve immediately and enjoy!